A forty five-year-old Boston-area man with a uncommon autoimmune dysfunction suffered from an energetic novel coronavirus an infection for 5 months, throughout which the pathogen mutated a number of instances earlier than he finally died, medical researchers say.
The case, detailed in The New England Journal of Medicine, has drawn the eye of pros researching the SARS-CoV-2 virus that causes COVID-19. They consider it could result in the origin of the variants of the illness which have emerged, akin to these from South Africa and Britain, New York Fox network affiliate WNYW said on its website.
The affected person suffered from Antiphospholipid syndrome, an autoimmune dysfunction that prompted his physique to mistakenly goal proteins within the blood that forestall clotting. He was required to take medicine to suppress his immune system.
He was admitted to Brigham and Women’s Hospital, the educating hospital for Harvard Medical School, a number of instances for recurrence of the an infection and handled with antiviral drugs and experimental antibody medicine.
“We think that this situation, where his immune system was weakened but still able to mount some response, allowed the virus to pretty much live in an environment where it had to change in order to survive,” stated Dr. Jonathan Li, an infectious illness doctor at Harvard Medical School who runs a virology laboratory and studied the person’s case.
“The patient that we studied had detectable, high levels of virus for five months. This was a highly unusual situation,” he stated.
Since the affected person’s immune system could not utterly expunge or kill the virus, it successfully compelled the virus to mutate and alter, Li stated.
“We don’t know exactly where some of these new variants came from,” Li said. “But I think it’s one of the leading hypothesis that it’s a patient like this gentleman that I helped study — that it’s this kind of immunosuppressed situation that could have led to some of these emerging variants.”
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